Cholinergic urticaria with associated angio-oedema

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Abstract
Three patients are described who developed angio-edema and urticaria after a hot bath challenge and physical exercise. In 1 patient this was accompanied by a fall in peak expiratory flow rate. Blood levels of smooth muscle biological activity, measured using a bioassay, increased in all patients after experimental challenge. The association of angio-edema with cholinergic urticaria is emphasized and possible mechanisms discussed.

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