QUANTITATIVE MEASUREMENTS OF CEREBRAL BLOOD FLOW IN THE MACACQUE MONKEY

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Abstract
In 19 monkeys anesthetized with nembutal and with the basilar artery closed, blood flow through both internal carotids was measured by a modification of the "simple flowmeter" of Soskin; in 3 animals simultaneous measurements were made of flow through the basilar artery. Avg. figure for total "normal" cerebral blood flow was 0.86 cc./g./min. at an avg. blood pressure of 125 mm. Hg. Flow was not significantly affected by stimulation of the cervical sympathetic nerves. It was increased markedly by anoxemia. less markedly by hyper-capnia. and it tended to fall during inhalation of O2. It was greatly changed, without corresponding changes in blood pressure, by drugs injected into the arterial stream affluent to the brain: adrenalin and benzedrine reduced the flow and histamine. nitroglycerin, caffeine, theophylline, mecholyl, and metrazol (the latter causing convulsions) increased it. When given intraven. the same drugs had less effect on cerebral blood flow but adrenalin still tended to reduce it (after an initial increase) and caffeine and theophylline to increase it. Insulin caused a temporary fall in blood pressure and cerebral flow followed this apparently passively; convulsions produced by insulin or metrazol are not referable to primary effects on cerebral blood vessels. In the 3 animals in which carotid and basilar flows were both measured the basilar : carotid ratio was 26, 43, and 80%, indicating that the size of this anastomosis is verv variable.

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