Simple, Safe, Large Scale Synthesis of 5-Arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-Arylpropanoic Acids
- 1 October 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (19) , 3067-3074
- https://doi.org/10.1080/00397919508011439
Abstract
Reaction of aryl aldehydes with Meldrum's acid 2 in the presence of formic acid and triethylamine gives 5-arylmethyl Meldrum's acid derivatives 4 at room temperature, whereas at 80–100°C 3-arylpropanoic acids 5 are formed.Keywords
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