Interruption of the middle cerebral artery in 10‐day‐old rat alters normal development of distal collaterals

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Abstract
Pial surface arterioles join rami of the anterior and middle cerebral arteries (MCA) in 10‐day‐old normal Wistar rats. Normally, the anastomosing branches differentiate into small‐diameter vessels with significantly greater tortuosity (length) by 56 days of age. After interruption of the MCA in 10‐day‐old rats, large‐diameter, relatively straight collaterals were observed 46 or 90–110 days later. Evidently altered hemodynamic factors, as the result of MCA interruption, prevent the development of a normal pattern of arterioles and augment the development of an anomalous pattern of collaterals in young Wistar rats.