Characterization of isogenic carp (Cyprinus carpio L.) lines with a genetically determined high or low antibody production

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Abstract
Summary: Antibody production to dinitrophenyl‐keyhole limpet haemocyanin (DNP‐KLH) served as the immune parameter to divergently select carp (Cyprinus carpio L.) to produce high‐ and low‐responder F, hybrid lines. Antibody production to trinitrophenyl‐lipopolysaccharide [TNP‐LPS) and to DNP‐KLH were similar in magnitude. By contrast, some high‐responder lines were low responders to DNP‐human serum albumin, and vice versa. Low‐responder carp were relatively susceptible to infection with the parasite Trypanoplasma borreli. This suggested that at least one gene with a major influence on resistance differed between the two homozygous parents (69, 85) used to generate the high‐ and low‐responder homozygous families, respectively. The isogenic lines showed no within‐line variation in DNA fingerprints, but differed with respect to their MhcCyca‐DAB genes.