Landscape Ecology of Sylvatic Chikungunya Virus and Mosquito Vectors in Southeastern Senegal

Open Access
Publisher Website
Google Scholar
Abstract
The risk of human infection with sylvatic chikungunya (CHIKV) virus was assessed in a focus of sylvatic arbovirus circulation in Senegal by investigating distribution and abundance of anthropophilic Aedes mosquitoes, as well as the abundance and distribution of CHIKV in these mosquitoes. A 1650 km2 area was classified into five land cover classes: forest, barren, savanna, agriculture and village. A total of 39,799 mosquitoes was sampled from all classes using human landing collections between June 2009 and January 2010. Mosquito diversity was extremely high, and overall vector abundance peaked at the start of the rainy season. CHIKV was detected in 42 mosquito pools. Our data suggest that Aedes furcifer, which occurred abundantly in all land cover classes and landed frequently on humans in villages outside of houses, is probably the major bridge vector responsible for the spillover of sylvatic CHIKV to humans. Chikungunya is a mosquito-borne virus that infects and sickens people in many tropical, urban regions of the world. This virus circulates in forest cycles of West Africa, where mosquitoes transmit it among non-human primates. It also infects humans via bridge vectors, mosquitoes that feed on both non-human primates and humans. To date, little is known about the environmental factors that influence the abundance and distribution of mosquito vectors that participate in the forest cycle of this virus or about specific mosquitoes that are likely to act as bridge vectors. We studied the distribution and abundance of mosquitoes potentially involved in the forest cycle in southeastern Senegal, as well as their infection by this virus. Satellite imagery was used to classify the region into the 5 most abundant land cover elements, and mosquitoes attracted to humans were collected in sites representing each land cover class. We found that Aedes furcifer, a mosquito that occurs in all land cover types and also enters villages to feed on humans, is probably the most important bridge vector between forest circulation and human populations.