Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet.
Open Access
- 31 August 1987
- Vol. 28 (9) , 1073-1076
- https://doi.org/10.1136/gut.28.9.1073
Abstract
Intestinal permeability to sugar has been used as an objective measure of small bowel integrity to assess the efficacy of an elemental diet as the sole treatment or Crohn's disease of the small bowel. Fourteen children aged 11-17 years with active small bowel Crohn's disease were given an elemental diet for six weeks. Investigations with iso-osmolar oral test solutions before and after this treatment showed that all 14 children had abnormally raised lactulose/L-rhamnose permeability ratios, which fell significantly after the elemental diet. This change coincided with marked clinical improvement, as assessed by a disease activity index score.This publication has 17 references indexed in Scilit:
- Remission induced by an elemental diet in small bowel Crohn's disease.Archives of Disease in Childhood, 1987
- Intestinal permeability and lactose hydrolysis in human rotaviral gastroenteritis assessed simultaneously by non‐invasive differential sugar permeationEuropean Journal of Clinical Investigation, 1986
- Intestinal Absorption and Unmediated Permeation of Sugars in Post-Infective Tropical Malabsorption (Tropical Sprue)Digestion, 1986
- Intestinal Sugar PermeabilityJournal of Pediatric Gastroenterology and Nutrition, 1985
- Histological diagnosis of chronic inflammatory bowel disease in childhood.Gut, 1985
- Elemental diet in acute Crohn's diseaseArchives of Disease in Childhood, 1983
- Gastrointestinal permeability changes in the preterm neonate.Archives of Disease in Childhood, 1982
- Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel.Gut, 1981
- ABNORMAL INTESTINAL PERMEABILITY TO SUGARS IN VILLOUS ATROPHYThe Lancet, 1979
- A clinical scoring system for chronic inflammatory bowel disease in childrenDigestive Diseases and Sciences, 1979