Derivatives of 6-aminopenicillanic acid. Part XI. α-Amino-p-hydroxy-benzylpenicillin
- 1 January 1971
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 1920-1922
- https://doi.org/10.1039/j39710001920
Abstract
α-Amino-p-hydroxyphenylacetic acid was resolved and the isomeric amino-acids were coupled with 6-aminopenicillanic acid by two methods to give both epimers of α-amino-p-hydroxybenzylpenicillin. The epimer derived from (–)-D-α-amino-p-hydroxyphenylacetic acid has a broad spectrum of antibacterial activity and is exceptionally well absorbed into the bloodstream after administration by mouth.Keywords
This publication has 0 references indexed in Scilit: