Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae
- 1 February 1989
- journal article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 1989 (Supplement) , 145-148
- https://doi.org/10.1242/jcs.1989.supplement_12.12
Abstract
In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a ‘checkpoint’. Four additional genes have been identified that are also components of the RAD9 checkpoint.Keywords
This publication has 8 references indexed in Scilit:
- DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 geneCell, 1989
- Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin.The Journal of cell biology, 1988
- The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiaeScience, 1988
- Spindle formation and chromatin condensation in cells blocked at interphase by mutation of a negative cell cycle control geneCell, 1988
- Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian CellsScience, 1986
- ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAEGenetics, 1985
- THE IMPORTANCE OF DNA DOUBLE-STRAND BREAK REPAIR IN YEASTPublished by Elsevier ,1978
- A genetic study of X-ray sensitive mutants in yeastMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974