Synthesis of carbon‐14 and tritium labeled glyburide
- 1 January 1973
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 9 (1) , 91-105
- https://doi.org/10.1002/jlcr.2590090112
Abstract
N‐[4‐]2‐(5‐Chloro ‐2‐methoxybenzamido) ethyl phenylsulfonyl N′ ‐cyclohexylurea, IXc, or glyburide, has been labeled with tritium and carbon‐ 14. The tritium label is located in the C‐3 position of the 5‐chloro ‐2‐methoxybenzoyl portion of the molecule, while the carbon‐14 label is incorporated into the C‐2 position of the 2‐phenlethylamine moiety in the compound.The specific activities of the tritium and carbon‐14 labeled products are 8.50 mCi/mM and 3.66 mCi/mM, respectively.Keywords
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