Horseshoe Crab Lactate Dehydrogenase: Tissue Distribution and Molecular Weight
- 13 February 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3920) , 994-996
- https://doi.org/10.1126/science.167.3920.994
Abstract
Lactate dehydrogenase from Xiphosura (Limulus) polyphemus i D(-)-lactate specific. It does not use L(+)-lactate, α-hydroxybutyrate, α-hydroxyvalerate, or α-hydroxyisocaproate as substrate. In most tissues lactate dehydrogenase is composed of five isozymes with a molecular weight of 140,000 for each, as judged by gel-filtration chromatography. This suggests that the isozyme, are tetramers comprised of varying amounts of two physicochemically distinc subunits.Keywords
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