THE EFFECT OF THE INGESTION OF GLYCINE, WITH AND WITHOUT UREA, UPON CREATINE-CREATININE EXCRETION IN THE RAT AND MAN

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Abstract
When a stock diet, containing 5% of urea, or 5% of glycine, or 5% of both, or double these amts., was fed to normal young rats, the usual increases in muscle creatine were observed, but no increases in creatinine excretion. Creatine synthesis was directly proportional to the conc. of glycine or urea fed. When 5 g. of glycine or 5 g. of urea were ingested separately by a human subject, 97% of the theoretical amts. of creatine and creatinine which could be formed from these substances were excreted. When . glycine and urea were ingested together, 94.6% of the theoretical amts. of creatine and creatinine were excreted. Similar but much less striking results were obtained in another subject. Thus when glycine or urea is fed to rats and to man, urea or glycine can be supplied for creating synthesis. In man both creatine and creatinine can probably be synthesized from urea and glycine when they are ingested separately or together.

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