Brain-associated small-cell lung cancer antigen (BASCA) is expressed in developing lung: an immunohistochemical and immunoelectron microscopic study.
Open Access
- 1 January 1990
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 38 (1) , 51-57
- https://doi.org/10.1177/38.1.1688449
Abstract
Expression of brain-associated small-cell lung cancer antigen (BASCA) in developing lung and in lung tumors was investigated immunohistochemically and immunoelectron microscopically with monoclonal antibodies recognizing different epitopes of BASCA. In fetal lung, epithelial and mesenchymal cells had different spatial and temporal expression patterns, in contrast to the consistent pattern in neural cells. The cell membranes of epithelial cells of the proximal bronchial tubes were diffusely positive at the pseudoglandular stage. Ciliated cells lost immunoreactivity shortly after their emergence, but non-ciliated cells, including endocrine cells, lost it at the alveolar stage. The immunoreactivity in mesenchymal cells was reduced in the proximal airway, but positivity remained in the distal lung later during the postnatal period. All endocrine tumors of the lung, defined by diffuse synaptophysin immunoreactivity, expressed BASCA, but some non-endocrine carcinomas which also lacked densely cored granules ultrastructurally, showed BASCA positivity. The temporal and spatial pattern of BASCA expression in the developing lung suggests that BASCA plays an active role in lung morphogenesis. BASCA may be expressed as an oncofetal substance in some non-endocrine carcinomas of the lung.This publication has 11 references indexed in Scilit:
- PRESENCE OF THE LONG-CHAIN FORM OF POLYSIALIC ACID OF THE NEURAL CELL-ADHESION MOLECULE IN WILMS TUMOR - IDENTIFICATION OF A CELL-ADHESION MOLECULE AS AN ONCODEVELOPMENTAL ANTIGEN AND IMPLICATIONS FOR TUMOR HISTOGENESIS1988
- IMMUNOCYTOCHEMICAL DETECTION OF HUMAN-LUNG CANCER HETEROGENEITY USING ANTIBODIES TO EPITHELIAL, NEURONAL, AND NEUROENDOCRINE ANTIGENS1987
- Synaptophysin expressed in the bronchopulmonary tract: Neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasmsDifferentiation, 1987
- Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryosDevelopmental Biology, 1987
- ISOLATION OF SMALL-CELL LUNG CANCER-ASSOCIATED ANTIGEN FROM HUMAN-BRAIN1987
- MONOCLONAL-ANTIBODY THAT DISTINGUISHES SMALL-CELL LUNG-CANCER FROM NON-SMALL-CELL LUNG-CANCER1987
- 2 NOVEL CELL-SURFACE ANTIGENS ON SMALL-CELL LUNG-CARCINOMA DEFINED BY MOUSE MONOCLONAL-ANTIBODIES NE-25 AND PE-351986
- MONOCLONAL-ANTIBODIES TO SURFACE-ANTIGENS OF SMALL CELL-CARCINOMA OF THE LUNG1984
- STRUCTURE OF ALVEOLAR EPITHELIAL-CELLS IN PATIENTS WITH FIBROTIC LUNG DISORDERS1982
- ATYPICAL ENDOCRINE TUMORS OF THE LUNG1981