PRIMARY THROMBOCYTHEMIA - CLONAL ORIGIN OF PLATELETS, ERYTHROCYTES, AND GRANULOCYTES IN A GDB GDMEDITERRANEAN SUBJECT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 59  (1) , 76-79
Abstract
A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (GdB/GdMed), was investigated to test for the clonal origin of this myeloproliferative disorder. To assess somatic cell mosaicism in various tissues, the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant was used. Essential thrombocythemia is apparently a clonal disease involving the erythrocytic, granulocytic and megakaryocytic series without affecting monocytes, T lymphocytes and non-T lymphocytes.