DISCHARGE OF NEWLY SYNTHESIZED PROTEINS IN PURE JUICE COLLECTED FROM HUMAN PANCREAS - INDICATION OF MORE THAN ONE POOL OF INTRACELLULAR DIGESTIVE ENZYMES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 72  (3) , 417-420
Abstract
The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1 min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the acinar lumen was 36 .+-. 8 min. Stimulation of protein secretion by a rapid i.v. injection of caerulein (40 ng/kg), 1 h after [75Se]methionine administration, greatly decreased (by 73% on an average) the specific radioactivity of the discharged proteins. The concept of a functional heterogeneity of proteins secreted by the human pancreas was supported.

This publication has 7 references indexed in Scilit: