Immunoassay of 6-Hydroxymelatonin Sulfate in Human Plasma and Urine: Abolition of the Urinary 24-Hour Rhythm with Atenolol*
- 1 June 1985
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 60 (6) , 1166-1173
- https://doi.org/10.1210/jcem-60-6-1166
Abstract
An assessment of the rhythmic characteristics of melatonin secretion in manand other species requires the determination of 24-h secretion profiles. Measurement of a major excreted metabolite would allow noninvasive study of pineal function, applicablein particular to pediatric and long term circadian rhythm studies. This report describesa simple and rapid RIA for 6-hydroxymelatonin sulfate in human plasma and urine. Physiological studies revealed that both plasma and urinary levels of 6-hydroxymelatonin sulfate were closely related to plasma melatonin, and that the urinary 24-h rhythm was abolished by the β1-adrenergic anagonist atenolol. {J Clin Endocrinol Metab60:1166, 1985)Keywords
This publication has 1 reference indexed in Scilit:
- Measurement of 6-hydroxymelatonin in human urine and its diurnal variationsLife Sciences, 1980