Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
- 25 February 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4587) , 979-980
- https://doi.org/10.1126/science.6823561
Abstract
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two of these patients revealed primarily 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) with trace amounts of 1-methyl-4-phenyl-4-propionoxy-piperidine (MPPP). On the basis of the striking parkinsonian features observed in our patients, and additional pathological data from one previously reported case, it is proposed that this chemical selectively damages cells in the substantia nigra.This publication has 3 references indexed in Scilit:
- Chronic parkinsonism secondary to intravenous injection of meperidine analoguesPsychiatry Research, 1979
- Apraxia of Lid OpeningArchives of Ophthalmology (1950), 1965
- PIPERIDINE DERIVATIVES. PART III. 4-ARYLPIPERIDINES1The Journal of Organic Chemistry, 1947