Platelet Adhesion to Microcapsules with Different Potentials

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Abstract
A promising possible application of microcapsules in the medical field is as artificial red blood cells (ARBC), to enclose a mammalian hemolysate or a Hb solution within an ultrathin polymer membrane. Microcapsules having the same surface composition but different surface potentials were prepared, and the effect of the surface potential of the microcapsules on rabbit platelet adhesiveness was studied. Platelet adhesion was facilitated by an increase in the surface potential of the microcapsules, and coating of the microcapsules with plasma caused no change in this trend of facilitated platelet adhesion, though the difference in surface potential disappeared after plasma coating. The surface potential of the microcapsules was concluded not to affect the platelet adhesion directly but to influence the adsorption of plasma components on the microcapsules, thereby producing changes in platelet adhesiveness.

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