Evidence for a direct effect of bacitracin on cell-mediated insulin degradation in isolated hepatocytes
- 15 August 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 206 (2) , 295-299
- https://doi.org/10.1042/bj2060295
Abstract
In freshly isolated [rat] hepatocytes, in which extracellular degradation of insuln was very low, the degradation velocity was 1st-order with respect to the amount of insulin bound at steady state. The addition of bacitracin decreased the degradation velocity considerably, so that a higher proportion of cell-associated radioactivity remained intact. Bacitracin apparently affects the mechanism of insulin processing by intact hepatocytes.This publication has 22 references indexed in Scilit:
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