Glycolipid modification of α2 interferon binding. Sequence similarity between the α2 interferon receptor and verotoxin (Shiga-like toxin) B-subunit
- 1 April 1992
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 283 (1) , 25-26
- https://doi.org/10.1042/bj2830025
Abstract
Previous studies have implicated the glycolipid receptor for the Escherichia coli-derived verotoxin, globotriaosylceramide (Gb3; Gal alpha 1-4Gal beta 1-4Glc-ceramide), in the mechanism of alpha 2 interferon signal transduction. Comparison of the amino acid sequence of the human alpha 2 interferon receptor with that of the B (receptor-binding)-subunit of verotoxin shows three regions of similarity which may provide a structural basis for alpha 2-interferon-receptor/Gb3 interaction.Keywords
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