Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes
Open Access
- 1 April 1999
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (4) , 937-939
- https://doi.org/10.1128/aac.43.4.937
Abstract
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae . This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae , 4 presented ISs in their ompK36 gene.Keywords
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