Intestinal Obstruction Associated with Cholestyramine Therapy

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Abstract
CHOLESTYRAMINE, a quaternary ammonium anion-exchange resin, has been used in the management of severe pruritus from obstructive jaundice1 and for hypercholesterolemia.2 This nonabsorbable resin binds bile salts in the gastrointestinal tract, thereby preventing normal terminal ileal reabsorption and enhancing fecal excretion. With complete biliary obstruction the drug is ineffective since only bile salts excreted through the intestinal epithelium can be bound. Cholestyramine has been efficacious in the management of so-called "intrahepatic biliary atresia," with relief of anorexia and pruritus, lowering of serum cholesterol and bilirubin, reduction in number and size of cutaneous xanthomas and improvement of liver function with the . . .

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