Pivmecillinam in the treatment of Salmonella carriers
- 1 January 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 3 (suppl B) , 103-107
- https://doi.org/10.1093/jac/3.suppl_b.103
Abstract
Twelve chronic Salmonella carriers were treated with pivmecillinam. Eight out of 12 were cured. One of the cured patients underwent cholecystectomy during the treatment period and 2 were only cured when a second high dose treatment was combined with cholecystectomy. In the 4 carriers not cured by antibiotic therapy resistant Salmonella emerged, though in only one case were these resistant to mecil linam. The frequency of the emergence of antibiotic resistance and of R -factor carrying strains was similar to that obtained after administration of ampicillin. Plasmid mediated resistance against pivmecillinam was found.Keywords
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