Iron Turnover Abnormalities in Patients Having Anemia: Serial Blood and in vivo Tissue Studies with Fe59

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Abstract
Serial changes in radioactivity of plasma and hemoglobin, and (by external gamma-fluorescence detectors) of activity present in spleen, marrow and liver were recorded on individuals after intraven. injn. of Fe59 globulin. Increased radioactivity was interpreted as indicating increased erythrocyte production or accumulation of hemoglobin from destroyed erythrocytes which had contained labeled Fe. A number of characteristic record patterns are found consistently associated with certain syndromes. Sites of extramedullary myelopoiesis are indicated. A rapid turnover through the abnormal liver Fe pool exists in active rheumatoid arthritis.