Synthesis of (+) and (−) Epibatidine
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (1) , 63-71
- https://doi.org/10.1080/00397919508010790
Abstract
A practical synthesis of epibatidine (1) was developed. The key step involved selective reduction of the 5,6-double bond of 7-(tert-butyloxy-carbonyl)-2-(2-chloro-5-pyridyl)-3-(phenylsulfonyl)-7-azabicyclo[2.2.1]-heptane-2,5-diene (4) using nickel boride.Keywords
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