Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase
- 1 January 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (1) , 111-116
- https://doi.org/10.1021/jm00379a020
Abstract
A number of compounds were synthesized and tested for their ability to realkylate the phosphonate anion of aged, soman-inhibited acetylcholinesterase. None were able to do so, but 2 of the compounds in particular, [2-(4-pyridyl)ethyl]diethylmethylammonium iodide and its 2-isomer, slowed the rate of aging significantly.This publication has 1 reference indexed in Scilit:
- Ageing and dealkylation of soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesteraseArchives of Biochemistry and Biophysics, 1967