The template properties of some oligodeoxynucleotides containing cytidine and guanosine
- 1 June 1986
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 23 (2) , 108-112
- https://doi.org/10.1007/bf02099904
Abstract
The co-condensation of guanosine- and cytidine-5′-phospho-2-methylimidazolide on various oligodeoxynucleotides containing C and G has been studied. We find that GC7 is an effective template for the incorporation of C into products of the form GnC, whereas C7G does not act as a template for C incorporation. The template C3GC3GC3GC3 directs the synthesis of complementary products, but the yield of long oligomers is very small. Templates in which G residues are contiguous or separated by a single C residue are ineffective, while templates containing the sequence GCCG are very inefficient. The significance of these findings in the context of prebiotic chemistry is discussed.This publication has 10 references indexed in Scilit:
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