Epstein-Barr Virus Entry Utilizing HLA-DP or HLA-DQ as a Coreceptor
- 1 March 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (5) , 2451-2454
- https://doi.org/10.1128/jvi.74.5.2451-2454.2000
Abstract
Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibility to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and serve as a coreceptor in EBV entry.Keywords
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