Na++ Cl−‐gradient‐driven, high‐affinity, uphill transport of taurine in human placental brush‐border membrane vesicles

Publisher Website
Google Scholar
Abstract
Uptake of taurine in human placental brush‐border membrane vesicles was greatly stimulated in the presence of an inwardly‐directed Na++ Cl−‐gradient and uphill transport of taurine could be demonstrated under these conditions. Na+as well as Cl−were obligatory for this uptake and both ion gradients could energize the uphill transport. This Na++ Cl−‐gradient‐dependent taurine uptake was stimulated by an inside‐negative membrane potential, demonstrating the electrogenicity of the process. The uptake system was highly specific for β‐amino acids and theKmof the system for taurine was 6.5 ± 0.4 μM.