A neuropeptide in mammalian tissues with physalaemin-like immunoreactivity

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Abstract
Several structurally related non-mammalian peptides, termed tachykinins, with biological activities similar to substance P were isolated. This similarity is due to a common COOH-terminal region, whereas the specific action of each member of the group depends on its unique NH2-terminal sequence. Based on these properties, parallel bioassays using numerous guinea-pig smooth muscle preparations and physiological parameters allow them to be generally distinguished. Bioassays are time consuming and not highly specific. Thus, a rapid physalaemin-specific radioimmunoassay was developed that led to the initial discovery of a substance in mammalian tissues with an immunoreactivity resembling that of the original amphibian peptide. Data are present on the distribution, localization and partial characterization of physalaemin-like immunoreactivity (PSLI) in tissues of the guinea-pig, mouse and rat.