FAILURE OF OVULATION CAUSED BY GABA IN THE IMMATURE RAT GIVEN PREGNANT MARE SERUM GONADOTROPIN

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Abstract
We report here that: 1) Gamma-acetylenic GABA(GAG), a GABA transaminass inhibitor which increases brain GABA levels,blocked PMS-induced ovulation in immature rats;2)the effect of GAG was antagonized by bicuculline and reversed by hCG and LHRH; 3)intraventricular injection of either GABA or GAG was able to block ovulation;4) in contrast,systemic administration of GABA had no effect on ovulation.The results suggest that GABA exerts at a central level an inhibitory action on the neuroendocrine mechanisms involved in the cyclic control of gonadotropin secretion.