Probleme der statistischen Auswertung von Überlebenszeitstudien

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Abstract
When analyzing clinical studies where the survival time of the patients or, more generally, the time to a certain event in the patients' clinical course is the main endpoint, several problems have to be taken into account. Most of these problems, e.g. incomplete data and follow-up of the patients, arise specifically from the factor time which plays the central role in these studies. How such problems should be incorporated into a statistical analysis and into a sensible interpretation of the results is demonstrated by means of the estimation of survival rates with the Kaplan-Meier-method.

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