Personality factors and drug effects in a controlled study of cyclazocine

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Abstract
The relationship between measurable personality factors and level of effects shown to the narcotic antagonist cyclazocine and placebo was investigated in a controlled study. An attempt also was made through case analysis to examine the association between dynamic aspects of personality and adverse drug effect. Hysteria scores on the MMPI [Minnesota Multiphasic Personality Inventory] were related significantly to self-reported effects under both the drug and placebo conditions. Clinical observations were examined retrospectively for 3 cases with adverse reactions and cited to support a dynamic theory that associated drug reactivity to personality factors in heroin addicts treated with this drug.

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