Advanced Alzheimer's Disease Is a Risk Factor for Late-Onset Seizures
- 1 August 1990
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 47 (8) , 847-850
- https://doi.org/10.1001/archneur.1990.00530080029006
Abstract
• To determine the role of Alzheimer's disease as a causative factor for lateonset epilepsy, 44 subjects with mild senile dementia of the Alzheimer type and 58 healthy control subjects were examined over a 90-month period for the development of focal or generalized seizure activity (excluding myoclonus). At entry, all subjects were free of prior seizures and other neurologic, medical, and psychiatric disorders with the potential to impair cognition. Although no control subject developed seizures during the study period, 7 subjects with senile dementia of the Alzheimer type had at least one documented seizure. All 7 subjects had progressed to the severe stage of dementia by the time of the first seizure. Seizures were generalized tonic-clonic in type and were unassociated with clinical or (in 3 subjects) neuropathologic evidence for epileptogenic factors other than Alzheimer's disease. We conclude that advanced Alzheimer's disease alone may be an important risk factor for new-onset seizures in older adults.This publication has 21 references indexed in Scilit:
- Epilepsy after strokeNeurology, 1987
- Late onset epileptic seizures A retrospective study of 250 patientsActa Neurologica Scandinavica, 1985
- Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer typeElectroencephalography and Clinical Neurophysiology, 1983
- Visual evoked potentials in mild senile dementia of alzheimer typeElectroencephalography and Clinical Neurophysiology, 1983
- Mild senile dementia of Alzheimer type: research diagnostic criteria, recruitment, and description of a study population.Journal of Neurology, Neurosurgery & Psychiatry, 1982
- A New Clinical Scale for the Staging of DementiaThe British Journal of Psychiatry, 1982
- The Epidemiology of Epilepsy in Rochester, Minnesota, 1935 Through 1967Epilepsia, 1975
- Seizures Beginning After the Age of 60Archives of internal medicine (1960), 1969
- Epilepsy after the age of 50Neurology, 1964
- Clinical Analysis of Morbus Alzheimer and Morbus PickActa Psychiatrica Scandinavica, 1953