Increased 2Nd Trimester Hemoglobin Concentration in Pregnancies Later Complicated by Hypertension and Growth Retardation: Early Evidence of a Reduced Plasma Volume

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Abstract
Second‐trimester hemoglobin (Hb) concentration was measured in 1 535 pregnancies. Mean Hb concentration was significantly increased in women who developed pregnancy‐induced hypertension (PIH) in the last trimester before the 37th week (p<0.01). A similar trend was also observed in nulliparous women who gave birth to infants with a birthweight below the 10th percentile, especially in smokers. the highest Hb concentrations were found in women with both PIH and intra‐uterine growth retardation (IUGR). These findings are in agreement with previous observations in smaller studies and indicate that a reduced plasma volume may already be present in the second trimester, before PIH and/or IUGR appear.

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