Huntington's Disease: Delayed Hypersensitivity in Vitro to Human Central Nervous System Antigens
- 21 January 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4275) , 314-316
- https://doi.org/10.1126/science.137525
Abstract
Huntington's disease is a hereditary, chronic, degenerative disease of the brain which is transmitted by an autosomal dominant gene. We have discovered that lymphocytes from patients with Huntington's disease respond to the presence of brain tissue from patients with the disease by producing migration inhibition factor, a correlate of the cellular immune response. Lymphocytes from donors without the disease do not respond to the diseased brain tissue, and lymphocytes from patients with Huntington's disease respond only rarely to brain tissue from donors without the disease.This publication has 3 references indexed in Scilit:
- STUDIES ON BRAIN BIOPSIES OF PATIENTS WITH HUNTINGTONʼS CHOREAJournal of Neuropathology and Experimental Neurology, 1974
- The Guillain-Barré Syndrome and Multiple SclerosisNew England Journal of Medicine, 1971
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968