The resolution of five linker histone subtypes from chicken erythrocytes

Abstract
A method is described for the isolation of 4 highly purified H1 linker histone subfractions, and histone H5, from chicken erythrocytes. Fractionation is achieved under non‐denaturing conditions by elution from CMC‐25 Sephadex with an NaCl gradient. When applied to calf thymus H1, the order of subtype elution differs from that acheived on Amberlite IRC‐50 [(1966) J. Biol. Chem. 241, 5790‐5797; (1976) Biochemistry 15, 4233‐4242]. The two column types employed in series could provide a means for improving subtype purity.