Synthetic Antispasmodics. I. Some 1,1-Diaryl-3-(4'-methyl-1'-piperazino)-1-propenes

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Abstract
The Mannich bases obtained by reaction of 1-methylpiperazine and formaldehyde with acetophenone and 2-acetylthiophen respectively have been condensed with phenyl- and α-thienylmagnesium bromide, giving the 1,1-diphenyl, 1,1-di-α-thienyl, and 1-phenyl-1-α-thienyl-3-(4'-methyl-1'-piperazino)propan-1-ols. These have been dehydrated to the corresponding 1-propenes. Both the propanols and the propenes exhibit antispasmodic activity.

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