The Molecular Defects of α-Thalassemia in the Filipino
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 1 (6) , 539-546
- https://doi.org/10.3109/03630267709003418
Abstract
Molecular hybridization with synthetic radioactive DNA (cDNA) complementary to a globin mRNA sequences shows that, as in most other Southeast Asian populations, the a globin structural genes are deleted in Filipinos affected by the α-thalassemia syndromes. Thus, all 4 α-globin structural genes are deleted in homozygous α-thalassemia with hydrops fetalis, 3 and 2 structural genes are deleted in hemoglobin H disease and α-thalassemia-1 respectively.This publication has 9 references indexed in Scilit:
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