Comparative Activity of Several Antimicrobial Agents against Nosocomial Gram‐Negative Rods Isolated across Canada

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Abstract
In 1992, a surveillance study was performed in Canada to determine the susceptibility of nosocomial Gram‐negative rods to several wide spectrum antimicrobials. Consecutive isolates from 10 institutions, as well as additional strains of selected species of Enterobacteriaceae that are known to possess the Bush group 1 beta‐lactamase, were tested for susceptibility to 12 antimicrobials. Third‐generation cephalosporin resistance was found to be as high as 29% in Enterobacter cloacae that possesses the Bush group 1 beta‐lactamase and less than 4% in those isolates not possessing this enzyme. Cefepime equalled or exceeded the activity of the third‐generation cephalosporins against the species of Enterobacteriaceae that demonstrated resistance to the third‐generation cephalosporins.