Chemical and Pharmacological Studies on N-Resulfated Heparin
- 1 April 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (4) , 901-905
- https://doi.org/10.3181/00379727-109-27372
Abstract
A method for synthesis of radioactive heparin of high unit activity and radioactivity has been described using a process of N-desulfation and N-resulfation. Comparison of the biological identity of the radioactive material with commercial heparin has been made. N-resulfated S35 heparin appears to be similar to biosynthetic S35 heparin in both its clearing and anticoagulant activity as well as its ultimate fate and distribution in the body.Keywords
This publication has 6 references indexed in Scilit:
- Blood levels and clearing activity of a synthetic heparinoidBiochemical Pharmacology, 1961
- Distribution and Excretion of HeparinExperimental Biology and Medicine, 1961
- The Synthesis of Heparin by Slices of Mouse Mast Cell TumorJournal of Biological Chemistry, 1959
- Physiological Disposition of Heparin.Experimental Biology and Medicine, 1958
- THE INCORPORATION OF S35-SULFATE INTO HEPARINJournal of Biological Chemistry, 1957
- The Relation between the Structure of Heparin and its Anticoagulant ActivityJournal of the American Chemical Society, 1945