Methylating and ethylating carcinogens have different requirements for poly(ADP-ribose) synthesis during malignant transformation

1 January 1984

journal article
research article
Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research

Vol. 5 (12) , 1573-1576
https://doi.org/10.1093/carcin/5.12.1573

Abstract

Transformation of mouse C3H 10T1/2 cells by various alkylating carcinogens was modulated by inhibiting poly(ADP-ribose) synthesis with a low concentration of 3-aminobenzamide, which induces no additional toxicity or reported side effects. Transformation by methylating agents was decreased by 3-aminobenzamide, transformation by ethylating agents was increased. These results confirm earlier work on transformation by methylating agents, X-rays and UV light. Transformation by ethylating agents appears to proceed by a different mechanism.

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