Human pituitary thyrotropin and gonadotropins: a comparative study of their in vitro lipolytic activity
- 1 April 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 55 (4) , 282-285
- https://doi.org/10.1139/o77-039
Abstract
Highly purified preparations of human thyrotropin [TSH], follitropin [follicle stimulating hormone, FSH] and choriogonadotropin [human chorionic gonadotropin, HCG] were evaluated for their ability to stimulate lipolysis in isolated rat adipocytes. TSH was the most active of all, while FSH showed some activity. LH and HCG were essentially inactive. The isolated subunits of TSH were inactive, and 60-100% activity was regenerated upon recombination. Lipolytic activity is intrinsic to human TSH. The hybrid of human LH .alpha. + TSH .beta. was considerably less active than the natural recombinant (TSH .alpha. + .beta.), possibly indicating the presence of some differences in the .alpha. subunits.This publication has 4 references indexed in Scilit:
- Some Chemical and Physical Properties of Human Pituitary Follicle-Stimulating Hormone*Biochemistry, 1967
- METABOLISM OF ISOLATED FAT CELLS .I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM + LIPOLYSIS1964
- Adipokinetic Actions of Adrenocorticotropin, Thyroid-Stimulating Hormone, Vasopressin, α- and β-Melanocyte-Stimulating Hormones, Fraction H, Epinephrine and Norepinephrine in the Rabbit, Guinea Pig, Hamster, Rat, Pig and DogEndocrinology, 1963
- Studies on the Metabolism of Adipose Tissue: The Stimulation of Oxygen Consumption by TSH Preparations in Relation to Growth Hormone and Other Pituitary FractionsEndocrinology, 1962