Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Open Access
- 25 April 2007
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 27 (17) , 4598-4602
- https://doi.org/10.1523/jneurosci.0325-07.2007
Abstract
Long-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.Keywords
This publication has 16 references indexed in Scilit:
- Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiationNature Neuroscience, 2006
- Pathway-Specific Trafficking of Native AMPARs by In Vivo ExperienceNeuron, 2006
- Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain InteractionScience, 2000
- Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2Neuron, 1996
- Role of intercellular interactions in heterosynaptic long-term depressionNature, 1996
- Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channelsNeuron, 1995
- Cloned Glutamate ReceptorsAnnual Review of Neuroscience, 1994
- Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiationNeuron, 1992
- Philanthotoxin-343 blocks long-term potentiation in rat hippocampusNeuroReport, 1992
- A persistent postsynaptic modification mediates long-term potentiation in the hippocampusNeuron, 1988