High‐Temperature Short‐Time Heat Inactivation of HIV and Other Viruses in Human Blood Plasma
- 1 February 1992
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 62 (1) , 12-20
- https://doi.org/10.1111/j.1423-0410.1992.tb01160.x
Abstract
An ultra-short-time heating system was used to process blood plasma spiked with various viruses (HIV, vesicular stomatitis virus, encephalomyocarditis virus). Virus reduction and recovery of plasma proteins were measured at various temperatures from 65 to 85 degrees C. Processing at 77 degrees C and 0.006 s resulted in a high level of virus kill, including greater than or equal to 4.4 log10 HIV, while maintaining protein structure and activity essentially intact.Keywords
This publication has 15 references indexed in Scilit:
- Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetiiCellular Microbiology, 2007
- VIRUCIDAL TREATMENT OF CLOTTING FACTOR CONCENTRATESThe Lancet, 1988
- VIRUS SAFETY OF SOLVENT/DETERGENT-TREATED ANTIHAEMOPHILIC FACTOR CONCENTRATEThe Lancet, 1988
- Tri(n‐Butyl) Phosphate/Detergent Treatment of Licensed Therapeutic and Experimental Blood Derivatives1Vox Sanguinis, 1987
- Procedures for the inactivation of viruses in clotting factor concentratesAmerican Journal of Hematology, 1986
- Inactivation of viruses in labile blood derivatives. I. Disruption of lipid‐enveloped viruses by tri(n‐butyl)phosphate detergent combinationsTransfusion, 1985
- Thermal inactivation of the acquired immunodeficiency syndrome virus, human T lymphotropic virus-III/lymphadenopathy-associated virus, with special reference to antihemophilic factor.Journal of Clinical Investigation, 1985
- Reduction in Risk of Hepatitis Transmission by Heat-Treatment of a Human Factor VIII ConcentrateThe Journal of Infectious Diseases, 1984
- Plasma derivatives and viral hepatitisTransfusion, 1982
- Separation range and separation efficiency in high-speed gel filtration on TSK-GEL SW columnsJournal of Chromatography A, 1980