Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex.

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Abstract
The Ia [immune response] determinants expressed on nylon wool-purified T [thymus derived] lymphocytes reactive to concanavalin A (Con A) in serum-free media are coded in a single I subregion of the H-2 [histocompatability] gene complex. This region, I-J, is defined by 2 pairs of intra-H-2 recombinant haplotypes: H-2t3, H-2t4 and H-2i3, H-2i5, carried by B10.HTT, B10.S(9R), B10.A(3R) and B10.A(5R), respectively. No activity against Con A-reactive T cells was detected in any antiserum that was produced in strain combination which shared a common I-J region. Ia antigens expressed on Con A-reactive T cells may be restricted to the I-J subregion.

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