INFLUENCE ON THE REPLACEMENT VALUE OF SOME ADRENAL-CORTEX STEROIDS OF DIETARY SODIUM AND SYNERGISM OF STEROIDS IN LACTATING ADRENALECTOMIZED RATS
- 1 September 1952
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 51 (3) , 217-225
- https://doi.org/10.1210/endo-51-3-217
Abstract
A 2-fold increase in the Na content (from 0.33-0.67%) of the diet did not affect the replacement value of desoxycorticosterone acetate (DCA) (0.56 or 3.0 mg./day) or of 11-dehydrocorticosterone acetate (0.56 mg./day) in maintaining lactation in adrenalectomized rats. A 3-fold increase in the dietary Na (to 1.04%) was also without effect on the replacement value of DCA (0.56 mg./day) or 11-dehydrocorticosterone (0.5 mg./day). In 1 expt. 11-dehydrq-corticosterone acetate gave no lactational response in rats adrenalectomized on the 4th day of lactation; in the 2d expt. a slight but significant beneficial response was noted with the equivalent dose of 11-dehydrocorticosterone (0.5 mg./day). No synergistic effect was observed when 11-dehydrocorticosterone (0.5 mg./day) was given in conjunction with DCA (0.56 mg./day). Partial restoration of lactation was obtained in adrenalectomized rats by implanting cortisone (1 or 3,15-mg. tablets). Complete restoration of lactation, as estimated from the growth of the litters, was obtained when cortisone (211-mg. tablets) was implanted with DCA (150-mg. tablet). Appetite and body wt. were restored virtually to normal. Cortisone implants were absorbed somewhat more rapidly when the animal was also implanted with DCA.Keywords
This publication has 1 reference indexed in Scilit:
- Comparative Effects of Cortisone and 11-Deoxycorticosterone on Tissue Arginase Levels of Adrenalectomized Lactating RatsExperimental Biology and Medicine, 1951