THE ANTISCORBUTIC ACTIVITY OF L-ASCORBIC ACID PHOSPHATE GIVEN ORALLY AND PERCUTANEOUSLY IN GUINEA PIGS

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Abstract
The antiscorbutic activity of L-AsA [ascorbic acid] phosphate was studied in about 300 g male guinea pigs. By the oral administration, 2.1 mg/animal/day of L-AsA phosphate-Mg might prevent the development of scurvy. L-AsA seems to be more active than the equimole of L-AsA phosphate-Mg. By the percutaneous application such as a cosmetic cream, L-AsA phosphate-Mg was as active anti-scorbutically as L-AsA. The direct absorption of L-AsA phosphate through the skin and the hydrolysis in situ were suggested by the histo-chemical identification of AsA. The blood AsA level rapidly rose after the oral administration of L-AsA phosphate-Mg in normal guinea pigs fasted for 24 hr. L-AsA phosphate-Mg was shown to undergo hydrolysis in vitro by the homogenates of small intestine and liver or by the crude extracted solution of skin of guinea pigs.

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