OXYGEN TENSION AND pH OF THE RENAL CORTEX IN ACUTE ISCHEMIA AND CHRONIC HYPERTENSION

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Abstract
Expts. were performed to determine the pH and relative oxygen tension of the renal cortex in acute renal ischemia and in chronic renal hypertension in dogs anesthetized with Nembutal. In normal dogs progressive degrees of unilateral renal arterial constriction caused decreases in oxygen tension and marked acidity in the ischemic kidney. In chronic renal hypertensive dogs there was a change of pH in the acid direction and a decrease in oxygen tension of the renal cortex of the ischemic kidney as compared with the opposite one. Small doses of epinephrine appeared to cause less of a decrease in the oxygen tension of the renal cortex in both the chronic and acute ischemic kidney than in the contralateral kidney. In acute expts. oxygen tension first fell and then rose to normal levels with slight constriction of the renal artery. Under these conditions pH remained acidic.

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