The Location of the Bromelain Cleavage Site in a Hong Kong Influenza Virus Haemagglutinin
- 1 February 1981
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 52 (2) , 367-370
- https://doi.org/10.1099/0022-1317-52-2-367
Abstract
The site of bromelain cleavage in the hemagglutinin of the Hong Kong influenza virus A/Memphis/102/72 was determined using a diagonal peptide mapping procedure on the thermolytic digest of amidated BHA [truncated hemagglutinin obtained by bromelain digestion]. Bromelain cleavage removes the C-terminal 46 residues from HA2. The new C-terminal residue of BHA2 is Gly 175. This is close to the beginning of the hydrophobic membrane-interacting sequence that starts at residue 183.This publication has 1 reference indexed in Scilit:
- Crystallization and X-ray diffraction studies on the haemagglutinin glycoprotein from the membrane of influenza virusJournal of Molecular Biology, 1977